Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects

J Med Chem. 1998 Jun 18;41(13):2180-3. doi: 10.1021/jm980137o.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Benzopyrans / chemistry
  • Benzopyrans / metabolism
  • Benzopyrans / pharmacology*
  • Benzopyrans / toxicity
  • Biological Availability
  • Blood Pressure / drug effects
  • Brain / metabolism
  • Capillary Permeability / drug effects
  • Carotid Arteries / drug effects
  • Carotid Arteries / physiology
  • Cats
  • Cell Line
  • Drug Evaluation, Preclinical
  • Dura Mater / blood supply
  • Dura Mater / drug effects
  • Gorilla gorilla
  • Guinea Pigs
  • Hypothermia / metabolism
  • Inflammation / physiopathology
  • Migraine Disorders / drug therapy*
  • Piperazines / chemistry
  • Piperazines / metabolism
  • Piperazines / pharmacology*
  • Piperazines / toxicity
  • Receptor, Serotonin, 5-HT1D
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / metabolism
  • Serotonin Receptor Agonists / chemistry
  • Serotonin Receptor Agonists / metabolism
  • Serotonin Receptor Agonists / pharmacology*
  • Serotonin Receptor Agonists / toxicity
  • Stereoisomerism
  • Sumatriptan / metabolism
  • Sumatriptan / pharmacology
  • Sumatriptan / toxicity
  • Vascular Resistance / drug effects
  • Vasoconstrictor Agents / chemistry
  • Vasoconstrictor Agents / metabolism
  • Vasoconstrictor Agents / pharmacology*
  • Vasoconstrictor Agents / toxicity

Substances

  • Benzopyrans
  • PNU 109291
  • Piperazines
  • Receptor, Serotonin, 5-HT1D
  • Receptors, Serotonin
  • Serotonin Receptor Agonists
  • Vasoconstrictor Agents
  • Sumatriptan